All mitsumi'1s Applications !! (updated daily)

[mitsumi1]

proDAD Mercalli Plug-Ins Adobe 6.0.678.3

proDAD Mercalli Plug-Ins Adobe 6.0.678.3

Languages: Multilingual
File Size: 50.16 MB


Mercalli V6 Plug-Ins Adobe (Windows) - Image stabilization and optimization! Make your videos look pro with Mercalli Plug-Ins! Even faster, better, easier! proDAD's first Artificial Intelligence Application (AiA) for Adobe plugins.

Mercalli V6 Plug-Ins Adobe (Windows)
News editors, documentary producers, hobby videographers or Youtubers know it: That one moment that is so unique and important - and needs to be captured right NOW. Just shoot it now - and don't spend a lot of time worrying about settings or stabilizer hardware...

That's exactly what Mercalli enables you to do, because you can easily and quickly get the most out of that unique moment - now even supported by artificial intelligence! Wherever you are on the way, capture your best moments with the camera without having to think about whether the shot might be shaky or the lighting conditions don't fit. With Mercalli V6 Plug-Ins, you can always perfect your shots later with ease and just one click!
Less

Mercalli V6 Plug-Ins is a revolution in terms of performance and quality of CMOS and rolling shutter correction, optimizing where other stabilization mechanism fail or might be too slow. The further enhanced quality with significantly faster calculation and therefore minimal time expenditure now turns all your spontaneous shots into genuine highlights - often even in real-time!

The entirely new look and the very modern user interface makes working with Mercalli V6 Plug-Ins a very easy and intuitive affair. Mercalli V6 Plug-Ins allows you to achieve exactly the type of stabilization you want for your footage. For example, even ultra-wide-angle shots can be stabilized, with the unique fisheye look optionally preserved.

Our new "Artificial Intelligence Application" (shortly AiA) adjusts all parameters automatically for optimal stabilization and CMOS correction, thus helping you easily achieve astonishing results where even the predecessor version reached its limits. Don't just rely on your camera's internal stabilization, let Mercalli V6 Plug-Ins effortlessly extract the best from your video material.

Convince yourself now and test the free demo version of the new and best Mercalli V6 Plug-Ins! Get started right away!

Features
- Extremely fast stabilization
- Super fast CMOS analysis and rolling shutter correction
- Newly designed user interface
- Easy usability
- Artificial intelligence for user support ("AiA")
- Significantly fewer analysis runs compared to the predecessor
- Large selection of presets for many action cams and video cameras
- Stabilize ultra-wide-angle shots
- Retain fisheye look if needed

Release Notes
System Requirements
- Operating System: Windows 64 Bit: Vista, Win7, Win8, Win8.1, Win10, Win11
- Graphics card with 512MB and Shader 3.0

For cmosFIXR
High-performance graphics card with 1GB and Shader 3.0 with super-fast bus.


HOMEPAGE

https://www.prodad.com/Home-29756,l-us.html

DOWNLOAD

https://rapidgator.net/file/bbf635d62aa196d0d66420eb07253a75/Mercalli_Plug-Ins_Adobe_6.0.678.3.rar.html

https://ddownload.com/wnf8sm924wyn/Mercalli_Plug-Ins_Adobe_6.0.678.3.rar

 

[mitsumi1]

QuadSpinner Gaea 2.2.6 (x64)

QuadSpinner Gaea 2.2.6 (x64)

File Size: 53.7 MB


A new dawn for terrain design. Sophisticated and modern terrain design software for apex results in moments.

Pioneering tools.
Gaea's leading toolsets make realism a baseline. Streamlined workflows let you easily achieve your vision and work in tandem with your team.

Superior erosion.
The industry's most advanced and flexible erosion algorithm empowers you to create unlimited unique and believable terrains.

Artist-centric experience.
Our ultra-modern interface and myriad conveniences stimulate creativity, not constrict it. Working in Gaea is fun and can help you set a new performance standard.

Realism out-of-the-box.
Even the most basic shapes you create can be naturally authentic, original, and breathtaking. Our superior erosion suite gives you multiple ways to erode your terrains. All processes were designed for maximum appeal with minimum effort.

Primitive-based creation for instant results.
Primitives and other procedural tools let you put together an entire world fast. Choose from an arsenal of primitives, including hero mountain, mountain range, crater, and dunes - all pre-prepped for erosion.

Draw Mountains. Sculpt Erosion.
Gaea lets you draw mountains, islands, and continents of any shape and size. Directed Erosion allows you to sculpt erosion in high resolution for fine detailing - an industry first. Even when you sculpt by hand, it remains procedural.

Data Maps. Color Synthesis.
Unique Data Maps and color nodes are the foundation of Gaea's color production process. By layering and combining these maps, you can create complex textures that rival actual satellite imagery. The Vegetation node lets you add delicate foliage cover, and the Synth node creates textures from an image with a single click.

Cutting-edge workflow.
Gaea offers three different workflows to support your task or mood. Whether prototyping, building complex terrains, or finetuning details, you can enjoy a dedicated, streamlined workflow environment that will ultimately save you time.

What's New


HOMEPAGE

https://quadspinner.com

DOWNLOAD

https://rapidgator.net/file/42daa80fb844ca263a930a8b1b8540cb/Gaea-2.2.6.rar.html

https://ddownload.com/45wufgvazxof/Gaea-2.2.6.rar

 

[mitsumi1]

Schrodinger Suites 2025-4 (Win, Linux, macOS)

Free Download Schrodinger Suites 2025-4 | 32.9 Gb
Owner:Schrödinger, LLC
Product Name:Schrödinger Suites
Version:2025-4 Commercial Version *
Supported Architectures:x64
Website Home Page :www.schrodinger.com
Languages Supported:english
System Requirements:Windows, Linux, macOs **
Size:32.9 Gb
*Notes: All workflows that rely on Desmond are not supported on Windows or Mac platforms, they can only be run on Linux. This includes Molecular Dynamics, IFD-MD, FEP+, WaterMap, and a number of Materials Science workflows. GPU machine learning applications such as Active Learning Glide and DeepAutoQSAR on GPU can only be run on Linux.
Updated: Added Schrodinger_Suites_2025-4_Documentation
The software developerSchrödingercontinuously strive to develop scientific solutions that push the boundaries of molecular design and are delighted to share enhanced drug discovery and materials workflows inSchrödinger's 2025-4software release.


Small Molecule Drug Discovery
Platform Environment
Maestro Graphical Interface
- One-click deletion of empty project table columns: A single menu action instantly removes all empty property columns from the entire Project Table, decluttering the workspace to allow a clearer focus on relevant data.
- "Select Entries in Table" from workspace right-click menu: Right-clicking any atom in the Workspace instantly locates and selects its corresponding entry in the Project Table, eliminating the need for manual searching in large projects.
- Maestro Assistant (Beta) enhancements: Maestro Assistant is now more interactive with the addition of a command history, copy-to-clipboard functionality, clearer mode notifications, and a streamlined feedback system.
Binding Site & Structure Analysis
SiteMap
- SiteMap now evaluates more sites than requested, returning the requested number of top-scoring sites by SiteScore
Desmond Molecular Dynamics
- Energy Decomposition Analysis panel now supports trajectories generated using custom force field parameters
Mixed Solvent MD (MxMD)
- Addition of immiscible probes in Mixed Solvent MD to better identify cryptic pockets: Use hydrophobic probes to stabilize transiently exposed pockets in an open conformation to increase their residence time and facilitate cryptic binding site identification
Ligand Preparation
Pharmacophore Modeling
- Use 1D similarities to screen against massive virtual spaces defined combinatorically with the combinatorial_explorer workflow (command line only)
Lead Optimization
Ligand alignment
- Non macrocycle alignment jobs can run as interactive tasks without submitting a job
Enumeration
- Return only Pathfinder retrosynthetic routes that include purchasable starting materials
FEP+
- Added ligand atomic RMSF analysis for RE-FEP calculations
FEP Protocol Builder
- Enable separate solvent and complex hot atom rules including None
- Enable sampling between OPLS4 and OPLS5 with the new Force Field version parameter
Quantum Mechanics
- Predict optical rotation as a function of wavelength
- Added support for 18 new double hybrid functionals
- Faster simulations with optimized CPU assignments for unbalanced batch jobs and workflows
- Employ QRNN, MPNICE and UMA MLFFs from Jaguar interfaces
Medical Chemistry Design
Ligand Designer
- Interactive Core Hopping: A new Core Swap workflow supports non-ring cores and enables true core hopping transformations, allowing for the exploration of diverse chemical space directly within an interactive design environment.
- Manual attachment point selection for macrocyclization: The newly renamed Macrocyclization workflow allows for the interactive selection of attachment points, providing precise chemical control that focuses linker enumeration on synthetically relevant designs.
De Novo Design
- New PDF report for AutoDesigner workflows to record input settings and summarize enumeration and filtering results
Drug Formulations
Crystal Structure Prediction
- Expansion of drug formulations applicability with highly accurate Z'=2 polymorph predictions (Beta): Identify stable crystal polymorphs with updated crystal structure prediction capabilities to sample, search and rank confidently
Alternative Modalities
Bifunctional Degraders
- Optionally build linkers between the two warheads in both directions when using the "Linkers only" option in the Generate Degrader Ternary Complexes interface
- Prioritize ternary complexes for linker design with a new interface to score degrader ternary complexes powered by a validated Metadynamics-based workflow (beta)
Education Content
- New Learning Path: T Cell Receptor Engineering
- New Tutorial: Enzyme Engineering with BioLuminate
- Updated Tutorial: Validating a Protein Free Energy Perturbation Model for Thermostability Predictions for Single Point Mutations (previously "Obtaining Protein Free Energy Perturbation Thermostability Predictions for Single Point Mutations")
- Updated Tutorial: Improving the Thermostability of T4 Lysozyme Using Protein FEP+ Guided Design (previously "Introduction to Protein Thermostability Prediction using Protein FEP+")
- Updated Tutorial: Ligand Binding Pose Generation for FEP+ (previously Ligand Binding Pose Prediction for FEP+ using Core-Constrained Docking)
- Updated Tutorial: Structure-Based Virtual Screening using Glide
Biologics Drug Discovery
- Predict T-Cell Receptor structures using TCRBuilder2 through Maestro (full release)
- Improved ability to visualize sequences before and after CDR grafting in Antibody Humanization Panel by replacing the pop-up sequence viewer with the MSV
- Streamlined visualization and Descriptionting of mutation results by updating the mutations chart in the residue scanning results viewer interface
- Simpler analysis in the Residue Scanning Viewer by synchronization between chart and table
- In MM-GBSA Residue Scanning Viewer interface choose properties to Description on both axis, eg. Description affinity on x and stability on y-axis
- Easier setup of MM-GBSA Residue Scanning calculations through synchronization of selection between workspace and table, automatic fit-on selection, and ability to toggle visibility of select columns in property table
- New ASPmax protein descriptor capturing the maximum average surface property for aggregation propensity prediction (command line)
GUI for Quantum ESPRESSO
Product: Quantum ESPRESSO (QE) Interface
- (+DEFECT_FORMATION_ENERGY) Defect Correction: Workflow solution to compute the defect formation energy
- Upgrade to Quantum ESPRESSO 7.5
- Support for 3-body dispersion correction
- Visualization of d-band center
- Support for finite displacement phonon calculations
- Reduced disk space usage for phonon calculations
- Option to set self-consistency threshold for phonons
MS Surface
Product: MS SurfChem
- Desorption Enumeration: Active entry shown in the workspace
- Desorption Enumeration: Support for enumerating associate desorption products
Microkinetics
Product: MS Microkinetics
- Option to calculate the degree of selectivity control
- Option to Description degree of rate control per species
- Option to set pressure schedule per species
- Setup for transition state lateness parameter to define lateral interactions
- Setup for adsorbate-adsorbate interactions via lateral scaling parameter
- Support for saving and loading reaction network files
- Support for simplified reaction entry using plain text
- Support for loading a microkinetic model from a workspace entry
- Support for Descriptionting x-axis in log scale from the viewer panel
- User control over absolute and relative error tolerances
- Number of unphysical MKM steps displayed in viewer panel
Reactivity
Product: MS Reactivity
- Nanoreactor: Option to set spin for the final state of elementary reactions
- Nanoreactor: Refined setup for metadynamics cavity radius scaled from 0.1 to 1.0
- Nanoreactor: Product chemistry filtered by refined DFT or MLFF
- Nanoreactor: Reactant energy marked in the elementary reaction network mode
- Nanoreactor: Support for MLFF (UMA) energy refinement for open shell systems
- Reaction Network Profiler: Option to sort conformers from refined energy
Advanced Force Field Applications
Product: MS FF Applications
- Expanded support for MLFF selections in QM- and MD-based workflow solutions
- UMA (developed by Meta Platforms Inc.) added as MLFF option in QM-based workflows
- (+ENABLE_GRPC_MLFF_DESMOND) UMA (developed by Meta Platforms Inc.) added as MLFF option in MD-based workflows
Transport Calculations via MD simulations
Product: MS Transport
- Ionic Conductivity: Workflow solution to predict ionic conductivity in liquid electrolyte systems
- Viscosity: Option to turn off the SHAKE algorithm (command line)
- Viscosity: Support for MLFF
Coarse-Grained (CG) Molecular Dynamics
Product: MS CG
- Coarse-grained Mapping: Consistent, reusable names for sugar particles
- Coarse-grained Mapping: Improved restraint visualization
- Coarse-grained Mapping: MARTINI mapping of proteins
- Coarse-grained Mapping: MARTINI mapping of monosaccharides
- Coarse-grained Mapping: MARTINI mapping of cholesterol
- Coarse-grained Mapping: All-atom CMS created as input for CG FF Builder
- Coarse-Grained Mapping: Enhanced precision for SMARTS patterns to improve mapping and force field parameter reusability
- Coarse-Grained Mapping: Improved UX for the reuse of existing particle types
- Coarse-Grained Mapping: Visualization of the mapped system in the workspace
- Coarse-Grained Mapping: Use of antifreeze water molecules set by default
- CG FF Builder: NpT set as the default ensemble for MARTINI simulations
- CG FF Builder: Option to keep proteins rigid during the model building stage
- CG FF Builder: Option to set the masses to standard MARTINI particle types
- CG FF Builder: Mapping of a small ion-water cluster to a single MARTINI particle
- CG FF Builder: Support for the reuse of CG particle types with identical names
- CG FF Builder: Support for loading CG mapping output as input
Complex Bilayer Builder
Product: MS Complex Bilayer Builder
- Complex Bilayer: Model building solution for complex / multi-component bilayers of molecular materials including protein-based membranes
- Membrane Analysis: Workflow solution to analyze membrane structural features
Formulation ML
Product: MS Formulation ML
- Formulation ML: Support for parallel training and predictions of multiple models
- Formulation ML Optimization: Improved UX for loading models
- Formulation ML Optimization: Option to select random optimization for models
- Formulation ML Optimization: Option to stop optimization prior to convergence
- Formulation ML Optimization: Option for cost optimization
- Formulation ML Optimization: Support for composition constraints with Bayesian optimization
- ML Model Manager: Option to export and update descriptors for ingredients
- ML Model Manager: Automatic selection for the newly loaded model
- ML Model Manager: Access for model names to be edited by user
- ML Model Manager: Option to estimate MPO scores on model predictions
Layered Device ML
Product: MS Layered Device ML
- OLED Device ML: Advanced options for model training
- OLED Device ML: Option to export the training set data
- OLED Device ML: Support for parallel training and predictions of multiple models
- OLED Device ML: Option to use molecular model predictions as descriptors
MS Maestro User Interface
- Maestro: Job Monitor to display the cause of failures for failed jobs
- Maestro: Ribbon style enabled in the workspace for protein representations
MS Maestro Builders and Tools
- Complex Builder: Option to turn on/off IUPAC name assignment for ligands
- Complex Builder: Support for building dimers with an atom bridging two metals
- Disordered System: Preservation of protein residue information by default
- Disordered System: Option to set the system size by the total number of atoms
- Materials Science Panel Explorer: GUI to search and list panels by the application, method, chemistry, and product of interest
- Meta Workflows: Matched settings for the Brownie stage with the MD Multistage
- Optoelectronic Device Designer: Option to import materials data from a file
- Optoelectronic Device Designer: Option to export materials and device data
- Optoelectronic Device Designer: Option to remove materials from the database
- Optoelectronic Device Designer: Description for numerical energy levels
- Optoelectronic Device Designer: Description for numerical layer thicknesses
- Solvate System: Option to specify particle radii for coarse-grained models
- Solvate System, Structured Liquid GUI: (+MATSCI_PACKMOL_PBC) Periodic boundary conditions retained when building structures
Classical Mechanics
- Cluster Analysis: (+CLUSTER_DENSITY_PROFILE) Radial density profile for clusters
- Evaporation: Support for MLFF
- Evaporation: Setup for evaporation zone in radial distance from center of mass
- Polymer Crosslink: (+POLYMER_CROSSLINK_MODES) Option to select fast crosslinking mode
- Thin Plane Shear: Support for MLFF
- Thin Plane Shear: Option to use custom MLFF
- Umbrella Sampling: User control over potential of mean force (PMF) calculations
- Umbrella Sampling: Visualization of probability distribution overlap matrix
- Visualize Restraints: Visualization of multiple restraints
Quantum Mechanics
- Adsorption Site Finder: Support for MLFF
- Bond and Ligand Dissociation: Support for MLFF
- QM Multistage: Support for MLFF selection on the Theory tab
- Optoelectronic Film Properties: Advanced transition dipole moment analysis with distributions over angle, distance, and depth
- Probe Grid Scan: VdW radius used as atomic radius for metal atoms
- Probe Grid Scan: Support for scanning open shell systems using MLFF (UMA)
Education Content
- New Tutorial: Simulating Complex Protein Solutions
- New Tutorial: Creating a Coarse-Grained Model for Protein Formulations
- New Tutorial: Building and Analyzing a Complex Lipid Bilayer and Embedding a Membrane Protein
- New Tutorial: Ionic Conductivity
- New Tutorial: Optimizing Viscosity and Cost in Formulations with Missing Structural Data
- New Tutorial: Locating Adsorption Sites on Surfaces
- Updated Tutorial: Atomic Layer Deposition
- Updated Tutorial: Microkinetic Modeling
- Quick Reference Sheet: Materials Science Panel Explorer
Education Content
Life Science
- New Learning Path: T Cell Receptor Engineering
- New Tutorial: Enzyme Engineering with BioLuminate
- Updated Tutorial: Validating a Protein Free Energy Perturbation Model for Thermostability Predictions for Single Point Mutations (previously "Obtaining Protein Free Energy Perturbation Thermostability Predictions for Single Point Mutations")
- Updated Tutorial: Improving the Thermostability of T4 Lysozyme Using Protein FEP+ Guided Design (previously "Introduction to Protein Thermostability Prediction using Protein FEP+")
- Updated Tutorial: Ligand Binding Pose Generation for FEP+ (previously Ligand Binding Pose Prediction for FEP+ using Core-Constrained Docking)
- Updated Tutorial: Structure-Based Virtual Screening using Glide
Materials Science
- New Tutorial: Simulating Complex Protein Solutions
- New Tutorial: Creating a Coarse-Grained Model for Protein Formulations
- New Tutorial: Building and Analyzing a Complex Lipid Bilayer and Embedding a Membrane Protein
- New Tutorial: Ionic Conductivity
- New Tutorial: Optimizing Viscosity and Cost in Formulations with Missing Structural Data
- New Tutorial: Locating Adsorption Sites on Surfaces
- Updated Tutorial: Atomic Layer Deposition
- Updated Tutorial: Microkinetic Modeling
- Quick Reference Sheet: Materials Science Panel Explorer

Schrödinger Softwareprovide accurate, reliable, and high performance computational technology to solve real-world problems in life science research. It can be used to build, edit, run and analyse molecules. The Schrödinger-Suite of applications have a graphical user interface called Maestro. Using the Maestro you can prepare your structure for refinement. The following products are available: CombiClide, ConfGen, Core Hopping, Desmond, Epik, Glide, Glide, Impact, Jaguar ( high-performance ab initio package), Liaison, LigPrep, MacroModel, MCPRO+, Phase, Prime, PrimeX, QikProp, QSite, Semi-Empirical, SiteMap, and Strike.
Schrödinger Release 2025-4 | Life Science - New Features
Schrödinger Release 2025-4 | Materials Science - New Features
Schrödinger, LLCprovides scientific software solutions and services for life sciences and materials research, as well as academic, government, and non-profit institutions around the world. It offers small-molecule drug discovery, biologics, materials science, and discovery informatics solutions; and PyMOL, a 3D molecular visualization solution. The company was founded in 1990 and is based in Portland, Oregon with operations in the United States, Europe, Japan, and India.

Rapidgator
Documentation

https://rapidgator.net/file/9ac4287f23e6d3cb6dc91ef4f37b7496/gvomm.Schrodinger_Suites_2025-4_Documentation.rar.html

Linux

https://rapidgator.net/file/9e4963669661efbbb5c6fc7189e5827e/gvomm.Schrodinger_Suites_2025-4_Linux.part1.rar.html
https://rapidgator.net/file/e7a57a04b5df659ae13a95627ccfca1c/gvomm.Schrodinger_Suites_2025-4_Linux.part2.rar.html
https://rapidgator.net/file/7db722dc4818dd69f8e1025a88950e4d/gvomm.Schrodinger_Suites_2025-4_Linux.part3.rar.html

MacOSX

https://rapidgator.net/file/646b585de9f25e65d00a01b268a3edc6/gvomm.Schrodinger_Suites_2025-4_MacOSX.part1.rar.html
https://rapidgator.net/file/cc5968f273ba5361c8f916a133dfaea1/gvomm.Schrodinger_Suites_2025-4_MacOSX.part2.rar.html

Windows

https://rapidgator.net/file/c7600c5c4a204311ee7da126a2c1cf48/gvomm.Schrodinger_Suites_2025-4_Windows.part1.rar.html
https://rapidgator.net/file/6f7ef3f0f28673b7cc786caa7e4abf13/gvomm.Schrodinger_Suites_2025-4_Windows.part2.rar.html

Documentation

https://ddownload.com/e9vykjk22976/gvomm.Schrodinger_Suites_2025-4_Documentation.rar

Linux

https://ddownload.com/9buhmb7ldnd6/gvomm.Schrodinger_Suites_2025-4_Linux.part1.rar
https://ddownload.com/4qryqdnet0nl/gvomm.Schrodinger_Suites_2025-4_Linux.part2.rar
https://ddownload.com/jjxau3tjuyhf/gvomm.Schrodinger_Suites_2025-4_Linux.part3.rar

MacOSX

https://ddownload.com/kkgjtxzqdb9w/gvomm.Schrodinger_Suites_2025-4_MacOSX.part1.rar
https://ddownload.com/6sp8fxb4dkx8/gvomm.Schrodinger_Suites_2025-4_MacOSX.part2.rar
https://ddownload.com/mevw56iwnij9/gvomm.Schrodinger_Suites_2025-4_Windows.part1.rar
https://ddownload.com/za4ln818vc3z/gvomm.Schrodinger_Suites_2025-4_Windows.part2.rar

 

[mitsumi1]

Schrodinger Suites 2025-4 (Win, Linux, macOS)

Free Download Schrodinger Suites 2025-4 | 32.9 Gb
Owner:Schrödinger, LLC
Product Name:Schrödinger Suites
Version:2025-4 Commercial Version *
Supported Architectures:x64
Website Home Page :www.schrodinger.com
Languages Supported:english
System Requirements:Windows, Linux, macOs **
Size:32.9 Gb
*Notes: All workflows that rely on Desmond are not supported on Windows or Mac platforms, they can only be run on Linux. This includes Molecular Dynamics, IFD-MD, FEP+, WaterMap, and a number of Materials Science workflows. GPU machine learning applications such as Active Learning Glide and DeepAutoQSAR on GPU can only be run on Linux.
Updated: Added Schrodinger_Suites_2025-4_Documentation
The software developerSchrödingercontinuously strive to develop scientific solutions that push the boundaries of molecular design and are delighted to share enhanced drug discovery and materials workflows inSchrödinger's 2025-4software release.


Small Molecule Drug Discovery
Platform Environment
Maestro Graphical Interface
- One-click deletion of empty project table columns: A single menu action instantly removes all empty property columns from the entire Project Table, decluttering the workspace to allow a clearer focus on relevant data.
- "Select Entries in Table" from workspace right-click menu: Right-clicking any atom in the Workspace instantly locates and selects its corresponding entry in the Project Table, eliminating the need for manual searching in large projects.
- Maestro Assistant (Beta) enhancements: Maestro Assistant is now more interactive with the addition of a command history, copy-to-clipboard functionality, clearer mode notifications, and a streamlined feedback system.
Binding Site & Structure Analysis
SiteMap
- SiteMap now evaluates more sites than requested, returning the requested number of top-scoring sites by SiteScore
Desmond Molecular Dynamics
- Energy Decomposition Analysis panel now supports trajectories generated using custom force field parameters
Mixed Solvent MD (MxMD)
- Addition of immiscible probes in Mixed Solvent MD to better identify cryptic pockets: Use hydrophobic probes to stabilize transiently exposed pockets in an open conformation to increase their residence time and facilitate cryptic binding site identification
Ligand Preparation
Pharmacophore Modeling
- Use 1D similarities to screen against massive virtual spaces defined combinatorically with the combinatorial_explorer workflow (command line only)
Lead Optimization
Ligand alignment
- Non macrocycle alignment jobs can run as interactive tasks without submitting a job
Enumeration
- Return only Pathfinder retrosynthetic routes that include purchasable starting materials
FEP+
- Added ligand atomic RMSF analysis for RE-FEP calculations
FEP Protocol Builder
- Enable separate solvent and complex hot atom rules including None
- Enable sampling between OPLS4 and OPLS5 with the new Force Field version parameter
Quantum Mechanics
- Predict optical rotation as a function of wavelength
- Added support for 18 new double hybrid functionals
- Faster simulations with optimized CPU assignments for unbalanced batch jobs and workflows
- Employ QRNN, MPNICE and UMA MLFFs from Jaguar interfaces
Medical Chemistry Design
Ligand Designer
- Interactive Core Hopping: A new Core Swap workflow supports non-ring cores and enables true core hopping transformations, allowing for the exploration of diverse chemical space directly within an interactive design environment.
- Manual attachment point selection for macrocyclization: The newly renamed Macrocyclization workflow allows for the interactive selection of attachment points, providing precise chemical control that focuses linker enumeration on synthetically relevant designs.
De Novo Design
- New PDF report for AutoDesigner workflows to record input settings and summarize enumeration and filtering results
Drug Formulations
Crystal Structure Prediction
- Expansion of drug formulations applicability with highly accurate Z'=2 polymorph predictions (Beta): Identify stable crystal polymorphs with updated crystal structure prediction capabilities to sample, search and rank confidently
Alternative Modalities
Bifunctional Degraders
- Optionally build linkers between the two warheads in both directions when using the "Linkers only" option in the Generate Degrader Ternary Complexes interface
- Prioritize ternary complexes for linker design with a new interface to score degrader ternary complexes powered by a validated Metadynamics-based workflow (beta)
Education Content
- New Learning Path: T Cell Receptor Engineering
- New Tutorial: Enzyme Engineering with BioLuminate
- Updated Tutorial: Validating a Protein Free Energy Perturbation Model for Thermostability Predictions for Single Point Mutations (previously "Obtaining Protein Free Energy Perturbation Thermostability Predictions for Single Point Mutations")
- Updated Tutorial: Improving the Thermostability of T4 Lysozyme Using Protein FEP+ Guided Design (previously "Introduction to Protein Thermostability Prediction using Protein FEP+")
- Updated Tutorial: Ligand Binding Pose Generation for FEP+ (previously Ligand Binding Pose Prediction for FEP+ using Core-Constrained Docking)
- Updated Tutorial: Structure-Based Virtual Screening using Glide
Biologics Drug Discovery
- Predict T-Cell Receptor structures using TCRBuilder2 through Maestro (full release)
- Improved ability to visualize sequences before and after CDR grafting in Antibody Humanization Panel by replacing the pop-up sequence viewer with the MSV
- Streamlined visualization and Descriptionting of mutation results by updating the mutations chart in the residue scanning results viewer interface
- Simpler analysis in the Residue Scanning Viewer by synchronization between chart and table
- In MM-GBSA Residue Scanning Viewer interface choose properties to Description on both axis, eg. Description affinity on x and stability on y-axis
- Easier setup of MM-GBSA Residue Scanning calculations through synchronization of selection between workspace and table, automatic fit-on selection, and ability to toggle visibility of select columns in property table
- New ASPmax protein descriptor capturing the maximum average surface property for aggregation propensity prediction (command line)
GUI for Quantum ESPRESSO
Product: Quantum ESPRESSO (QE) Interface
- (+DEFECT_FORMATION_ENERGY) Defect Correction: Workflow solution to compute the defect formation energy
- Upgrade to Quantum ESPRESSO 7.5
- Support for 3-body dispersion correction
- Visualization of d-band center
- Support for finite displacement phonon calculations
- Reduced disk space usage for phonon calculations
- Option to set self-consistency threshold for phonons
MS Surface
Product: MS SurfChem
- Desorption Enumeration: Active entry shown in the workspace
- Desorption Enumeration: Support for enumerating associate desorption products
Microkinetics
Product: MS Microkinetics
- Option to calculate the degree of selectivity control
- Option to Description degree of rate control per species
- Option to set pressure schedule per species
- Setup for transition state lateness parameter to define lateral interactions
- Setup for adsorbate-adsorbate interactions via lateral scaling parameter
- Support for saving and loading reaction network files
- Support for simplified reaction entry using plain text
- Support for loading a microkinetic model from a workspace entry
- Support for Descriptionting x-axis in log scale from the viewer panel
- User control over absolute and relative error tolerances
- Number of unphysical MKM steps displayed in viewer panel
Reactivity
Product: MS Reactivity
- Nanoreactor: Option to set spin for the final state of elementary reactions
- Nanoreactor: Refined setup for metadynamics cavity radius scaled from 0.1 to 1.0
- Nanoreactor: Product chemistry filtered by refined DFT or MLFF
- Nanoreactor: Reactant energy marked in the elementary reaction network mode
- Nanoreactor: Support for MLFF (UMA) energy refinement for open shell systems
- Reaction Network Profiler: Option to sort conformers from refined energy
Advanced Force Field Applications
Product: MS FF Applications
- Expanded support for MLFF selections in QM- and MD-based workflow solutions
- UMA (developed by Meta Platforms Inc.) added as MLFF option in QM-based workflows
- (+ENABLE_GRPC_MLFF_DESMOND) UMA (developed by Meta Platforms Inc.) added as MLFF option in MD-based workflows
Transport Calculations via MD simulations
Product: MS Transport
- Ionic Conductivity: Workflow solution to predict ionic conductivity in liquid electrolyte systems
- Viscosity: Option to turn off the SHAKE algorithm (command line)
- Viscosity: Support for MLFF
Coarse-Grained (CG) Molecular Dynamics
Product: MS CG
- Coarse-grained Mapping: Consistent, reusable names for sugar particles
- Coarse-grained Mapping: Improved restraint visualization
- Coarse-grained Mapping: MARTINI mapping of proteins
- Coarse-grained Mapping: MARTINI mapping of monosaccharides
- Coarse-grained Mapping: MARTINI mapping of cholesterol
- Coarse-grained Mapping: All-atom CMS created as input for CG FF Builder
- Coarse-Grained Mapping: Enhanced precision for SMARTS patterns to improve mapping and force field parameter reusability
- Coarse-Grained Mapping: Improved UX for the reuse of existing particle types
- Coarse-Grained Mapping: Visualization of the mapped system in the workspace
- Coarse-Grained Mapping: Use of antifreeze water molecules set by default
- CG FF Builder: NpT set as the default ensemble for MARTINI simulations
- CG FF Builder: Option to keep proteins rigid during the model building stage
- CG FF Builder: Option to set the masses to standard MARTINI particle types
- CG FF Builder: Mapping of a small ion-water cluster to a single MARTINI particle
- CG FF Builder: Support for the reuse of CG particle types with identical names
- CG FF Builder: Support for loading CG mapping output as input
Complex Bilayer Builder
Product: MS Complex Bilayer Builder
- Complex Bilayer: Model building solution for complex / multi-component bilayers of molecular materials including protein-based membranes
- Membrane Analysis: Workflow solution to analyze membrane structural features
Formulation ML
Product: MS Formulation ML
- Formulation ML: Support for parallel training and predictions of multiple models
- Formulation ML Optimization: Improved UX for loading models
- Formulation ML Optimization: Option to select random optimization for models
- Formulation ML Optimization: Option to stop optimization prior to convergence
- Formulation ML Optimization: Option for cost optimization
- Formulation ML Optimization: Support for composition constraints with Bayesian optimization
- ML Model Manager: Option to export and update descriptors for ingredients
- ML Model Manager: Automatic selection for the newly loaded model
- ML Model Manager: Access for model names to be edited by user
- ML Model Manager: Option to estimate MPO scores on model predictions
Layered Device ML
Product: MS Layered Device ML
- OLED Device ML: Advanced options for model training
- OLED Device ML: Option to export the training set data
- OLED Device ML: Support for parallel training and predictions of multiple models
- OLED Device ML: Option to use molecular model predictions as descriptors
MS Maestro User Interface
- Maestro: Job Monitor to display the cause of failures for failed jobs
- Maestro: Ribbon style enabled in the workspace for protein representations
MS Maestro Builders and Tools
- Complex Builder: Option to turn on/off IUPAC name assignment for ligands
- Complex Builder: Support for building dimers with an atom bridging two metals
- Disordered System: Preservation of protein residue information by default
- Disordered System: Option to set the system size by the total number of atoms
- Materials Science Panel Explorer: GUI to search and list panels by the application, method, chemistry, and product of interest
- Meta Workflows: Matched settings for the Brownie stage with the MD Multistage
- Optoelectronic Device Designer: Option to import materials data from a file
- Optoelectronic Device Designer: Option to export materials and device data
- Optoelectronic Device Designer: Option to remove materials from the database
- Optoelectronic Device Designer: Description for numerical energy levels
- Optoelectronic Device Designer: Description for numerical layer thicknesses
- Solvate System: Option to specify particle radii for coarse-grained models
- Solvate System, Structured Liquid GUI: (+MATSCI_PACKMOL_PBC) Periodic boundary conditions retained when building structures
Classical Mechanics
- Cluster Analysis: (+CLUSTER_DENSITY_PROFILE) Radial density profile for clusters
- Evaporation: Support for MLFF
- Evaporation: Setup for evaporation zone in radial distance from center of mass
- Polymer Crosslink: (+POLYMER_CROSSLINK_MODES) Option to select fast crosslinking mode
- Thin Plane Shear: Support for MLFF
- Thin Plane Shear: Option to use custom MLFF
- Umbrella Sampling: User control over potential of mean force (PMF) calculations
- Umbrella Sampling: Visualization of probability distribution overlap matrix
- Visualize Restraints: Visualization of multiple restraints
Quantum Mechanics
- Adsorption Site Finder: Support for MLFF
- Bond and Ligand Dissociation: Support for MLFF
- QM Multistage: Support for MLFF selection on the Theory tab
- Optoelectronic Film Properties: Advanced transition dipole moment analysis with distributions over angle, distance, and depth
- Probe Grid Scan: VdW radius used as atomic radius for metal atoms
- Probe Grid Scan: Support for scanning open shell systems using MLFF (UMA)
Education Content
- New Tutorial: Simulating Complex Protein Solutions
- New Tutorial: Creating a Coarse-Grained Model for Protein Formulations
- New Tutorial: Building and Analyzing a Complex Lipid Bilayer and Embedding a Membrane Protein
- New Tutorial: Ionic Conductivity
- New Tutorial: Optimizing Viscosity and Cost in Formulations with Missing Structural Data
- New Tutorial: Locating Adsorption Sites on Surfaces
- Updated Tutorial: Atomic Layer Deposition
- Updated Tutorial: Microkinetic Modeling
- Quick Reference Sheet: Materials Science Panel Explorer
Education Content
Life Science
- New Learning Path: T Cell Receptor Engineering
- New Tutorial: Enzyme Engineering with BioLuminate
- Updated Tutorial: Validating a Protein Free Energy Perturbation Model for Thermostability Predictions for Single Point Mutations (previously "Obtaining Protein Free Energy Perturbation Thermostability Predictions for Single Point Mutations")
- Updated Tutorial: Improving the Thermostability of T4 Lysozyme Using Protein FEP+ Guided Design (previously "Introduction to Protein Thermostability Prediction using Protein FEP+")
- Updated Tutorial: Ligand Binding Pose Generation for FEP+ (previously Ligand Binding Pose Prediction for FEP+ using Core-Constrained Docking)
- Updated Tutorial: Structure-Based Virtual Screening using Glide
Materials Science
- New Tutorial: Simulating Complex Protein Solutions
- New Tutorial: Creating a Coarse-Grained Model for Protein Formulations
- New Tutorial: Building and Analyzing a Complex Lipid Bilayer and Embedding a Membrane Protein
- New Tutorial: Ionic Conductivity
- New Tutorial: Optimizing Viscosity and Cost in Formulations with Missing Structural Data
- New Tutorial: Locating Adsorption Sites on Surfaces
- Updated Tutorial: Atomic Layer Deposition
- Updated Tutorial: Microkinetic Modeling
- Quick Reference Sheet: Materials Science Panel Explorer

Schrödinger Softwareprovide accurate, reliable, and high performance computational technology to solve real-world problems in life science research. It can be used to build, edit, run and analyse molecules. The Schrödinger-Suite of applications have a graphical user interface called Maestro. Using the Maestro you can prepare your structure for refinement. The following products are available: CombiClide, ConfGen, Core Hopping, Desmond, Epik, Glide, Glide, Impact, Jaguar ( high-performance ab initio package), Liaison, LigPrep, MacroModel, MCPRO+, Phase, Prime, PrimeX, QikProp, QSite, Semi-Empirical, SiteMap, and Strike.
Schrödinger Release 2025-4 | Life Science - New Features
Schrödinger Release 2025-4 | Materials Science - New Features
Schrödinger, LLCprovides scientific software solutions and services for life sciences and materials research, as well as academic, government, and non-profit institutions around the world. It offers small-molecule drug discovery, biologics, materials science, and discovery informatics solutions; and PyMOL, a 3D molecular visualization solution. The company was founded in 1990 and is based in Portland, Oregon with operations in the United States, Europe, Japan, and India.

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Serv-U MFT Server (Serv-U File Server Platinum) 15.5.3.106

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Serv-U® offers secure and cost-effective file transfer solutions to meet the data transfer needs of both SMBs and large enterprises. Delivering simplicity in its secure FTP solutions, Serv-U enables fast and reliable B2B file transfer and ad hoc file sharing.


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Siemens Calibre 2024.1 Build 15.1 Linux

Free Download Siemens Calibre 2024.1 Build 15.1 Linux | 8.6 Gb
Siemens Digital Industries Softwarehas released Calibre 2024.1 is a suite of electronic design automation (EDA) software tools used for integrated circuit (IC) verification.
Owner:Siemens EDA (formerly Mentor Graphics)
Product Name:Calibre
Version:2024.1 (15.1) aoj
Supported Architectures:x86-64
Website Home Page :www.siemens.com
Languages Supported:english
System Requirements:Linux *
Size:8.6 Gb
Siemens Calibreis a suite of integrated circuit design tools designed for design engineers. These products enable users to perform physical verification of full-chip design layouts during the early stage in the design cycles, check against electrical and physical design rules, identify areas of layout with excess vulnerability to random particle defects, run signoff DRC and LVS checking of complete multi-die systems at any process node, and monitor standalone interposer/package connectivity without including the individual die design databases. Products include Calibre nmDRC, Calibre nmDRC Recon, Calibre Pattern Matching, Calibre Multi-Patterning, Calibre 3DSTACK, Calibre Auto Waivers, and Calibre YieldAnalyzer.



Shift Left with Calibre - Siemens

In this episode of Chalk Talk, Amelia Dalton and David Abercrombie from Siemens investigate the details of Calibre's shift-left strategy. They take a closer look at how the tools and techniques in this design tool suite can help reduce signoff iterations and time to tapeout while also increasing design quality.
Siemens Digital Industries Softwareis a global leader in the growing field of product lifecycle management (PLM), manufacturing operations management (MOM), and electronic design automation (EDA) software, hardware, and services. Siemens works with more than 100,000 customers, leading the digitalization of their planning and manufacturing processes.

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Synopsys Custom Compiler vV-2023.12 SP1 Linux

Free Download Synopsys Custom Compiler vV-2023.12 SP1 Linux | 12.4 Gb
Synopsys, Inc.has releasedCustom Compiler vV-2023.12 SP1is a fresh, modern solution for full-custom analog, custom digital, and mixed-signal integrated circuit (IC) design.
The Synopsys Custom Compiler design environment is a modern solution for full-custom analog, custom digital, and mixed-signal IC design. As the heart of the Synopsys Custom Design Family Custom Compiler provides design entry, simulation management and analysis, and custom layout editing features. It delivers industry-leading productivity, performance, and ease-of-use while remaining easy to adopt for users of legacy tools. The Custom Compiler design environment includes features for mixed-signal design entry, design debug, simulation management, analysis, and reporting. For layout, Custom Compiler provides fast and user-friendly polygon editing features and boosts productivity with its pioneering visually-assisted automation flow. Visually assisted automation is an innovative approach that delivers 2-10X better layout productivity-especially for difficult FinFET-based designs. Custom Compiler includes built-in verification features to catch physical and electrical errors during layout. These include design rule checking, electromigration checking, and resistance and capacitance extraction. The Custom Compiler design environment makes it easy to communicate design intent and achieve analog design closure, with support for templates and early parasitic simulation.
Owner:Synopsys Inc.
Product Name:Custom Compiler & PrimeWave Design Environment
Version:vV-2023.12 SP1
Supported Architectures:x86_64
Website Home Page :www.synopsys.com
Languages Supported:english
System Requirements:Linux *
Size:12.4 Gb


TheSynopsys PrimeWave Design Environmentis a comprehensive and flexible, AI-driven environment for simulation setup and analysis of analog, RF, mixed-signal design, custom-digital and memory designs within the Synopsys Custom Design Family. It delivers a seamless simulation experience around all the engines of Synopsys PrimeSim simulators, with comprehensive analysis, improved productivity, and ease of use. As a key component of the Synopsys AI-Driven Analog Design solution, the Synopsys PrimeWave Design Environment can optimize complex analog designs, across multiple test-benches and hundreds of PVT corners and quickly converge on optimal design points that meet engineer's specifications.
Synopsys Tool Tutorials
Synopsys, Inc.is the world leader in electronic design automation (EDA) software for semiconductor design. The company delivers technology-leading semiconductor design and verification platforms and IC manufacturing software products to the global electronics market, enabling the development and production of complex systems-on-chips (SoCs). Synopsys also provides intellectual property and design services to simplify the design process and accelerate time-to-market for its customers. Synopsys is headquartered in Mountain View, California and has offices in more than 60 locations throughout North America, Europe, Japan and Asia.

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Synopsys PrimeSim XA vW-2024.09 SP1 Linux

Free Download Synopsys PrimeSim XA vW-2024.09 SP1 Linux | 2.7 Gb
Synopsys, Inc.has releasedPrimeSim XA vW-2024.09-SP1, the leading FastSPICE technology for SRAM and mixed-signal verification.
PrimeSim XA simulator, an integral part of the PrimeSim solution is the leading FastSPICE for SRAM, Custom Digital and mixed-signal verification. PrimeSim XA's breakthrough patented technologies deliver superior performance and capacity while maintaining SPICE accuracy. Advanced simulation intelligence automatically recognizes devices, topologies and hierarchies and employs the most efficient techniques to accurately simulate any design type. PrimeSim XA is fully integrated with PrimeWave™, a newly architected design environment and waveform viewer that encapsulates analysis and display requirement that drastically improves productivity. Additionally, PrimeSim XA is a key engine inside the PrimeSim™ Reliability Analysis, a set of comprehensive solutions (Fault simulation, Static Circuit Check, IR/EM, Variation) that analyzes the full spectrum of a product life cycle, from early-life to end-of-life.
Owner:Synopsys
Product Name:PrimeSim XA
Version:vW-2024.09-SP1
Supported Architectures:x86_64
Website Home Page :www.synopsys.com
Languages Supported:english
System Requirements:Linux *
Size:2.7 Gb


10X Faster Analog Simulation with PrimeSim Continuum - Synopsys
In this video of Chalk Talk, Amelia Dalton chats with Hany Elhak from Synopsys about how the unified workflow of the PrimeSim Continuum from Synopsys can help you address systematic and scale complexity for your next IC design.
Synopsys, Inc.is the world leader in electronic design automation (EDA) software for semiconductor design. The company delivers technology-leading semiconductor design and verification platforms and IC manufacturing software products to the global electronics market, enabling the development and production of complex systems-on-chips (SoCs). Synopsys also provides intellectual property and design services to simplify the design process and accelerate time-to-market for its customers. Synopsys is headquartered in Mountain View, California and has offices in more than 60 locations throughout North America, Europe, Japan and Asia.

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TweakNow WinSecret Plus 7.4.2

TweakNow WinSecret Plus 7.4.2

File size: 25 MB


TweakNow WinSecret for Windows 10 and 11 allows users to explore the hidden settings in Windows.

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Show detail information about your system
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Protect your privacy by eliminating traces of your digital activities
Transparent Taskbar
Make your Windows Taskbar completely transparent
Troubleshooter
Fix problem with Internet connection, icon, thumbnail, and Microsoft Store
Windows Secret
Safely and easily explore Windows hidden settings

OS: Windows 10/11


HOMEPAGE

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VCap Downloader Pro 0.1.41.6837 Multilingual

VCap Downloader Pro 0.1.41.6837 Multilingual

File Size: 85.2 MB


VCap Downloader (VCapDL) is a universal software that allows you to capture video and audio from internet sites. The software interface resembles that of a regular browser, which makes it easier for the user to get to know and work with this software. The user just needs to copypast the video url from favorite browser and transfer it to VCap Downloader. VCap Downloader will capture the video and offer available quality for downloading. You can also extract audio track from any video and convert it to MP3 format.

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Support of 4K monitors

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Supports media stream M3U8, MPEG-DASH, VIMEO-STREAM protocols
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Watchdog Anti-Malware Premium / Business 4.3.520 Multilingual

Watchdog Anti-Malware Premium / Business 4.3.520 Multilingual

File size: 26.6 MB


Our highly acclaimed multi-engine anti-malware software helps keep your computer secure. Advanced Malware Detection and Removal, Browser Hijacker Removal, Effective Rootkit and Bootkit Detection and Removal, Real Time Protection, Anti Ransomware Protection Modules.

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Windows 10 Pro Lite / SuperLite 1809 Build 17763.8027 x64 Multilanguage Preactivat...

Free Download Windows 10 Pro Lite / SuperLite 1809 Build 17763.8027 x64 Multilanguage Preactivated AnkhTech
WPE+ Bootable | Language: English, Arabic, Spanish, Portuguese, French | File Size: 2.78 GB
Introducing 1 of best Windows 10 Pro Modified ISO with a Multi functional/Multi Purpose Boot. 5 Languages in installation and the ability to install more languages. Mainly for very low end specs, which can't run Windows 10 22H2. Performance, Speed and Stability.



Multi Functional Boot (WinPE)
- Multi Functional Powerful Boot with Professionals Programs to help you, Taskbar Shows up when you Move your Mouse Cursor Down in the Screen
- Take and Restore Backups, Test Your PC/Laptop Hardware, Do disk management tasks, Manage your files before installing the windows
Programs in Boot
- Monitor Test
- Unlocker
- 7zip
- AOMEI Partition Assistant
- Battery Mon
- BitlockerKey
- Boot Sect Gui
- BOOTICE
- Core Temp
- CPU-Z
- Crystal Disk Info
- Crystal Disk Mark
- Disk2VHD
- Everything
- Fast Copy
- File Explorer
- gimagex
- HD Speed
- HW Monitor
- HWinfo
- ImDisk
- Minitool Partitions wizard Ultimate
- NTFS Driver Protection
- NTPWedit
- PEPassPass
- Q-Dir
- Quick Memory Test
- Ram Test
- Search
- SearchMyFiles
- Snapshot
- Symantec Ghost
- Terabyte Image
- Windows Login Unlocker
- WinNT Setup
With 2 Editions you have the choice
1 - Windows 10 Pro Lite (1809)
Windows Features can be Modified , Install more Languages
2 - Windows 10 Pro SuperLite (1809)
Windows Features Can Not be Modified , Can Not Install more Languages , Very Fast installation and small sized Footprint after installation and higher speed system
Tweaks
- Photo Viewer Enabled
- Reserved Storage disabled
- Fast Startup enabled
- Reduce shutdown time
- Hibernation Disabled
- Updates Paused until 2050
Enabled
- Direct Play
- Legacy Components
- Net framework 3.5 installed
Features
- Updated .Net 4.7 to 4.8
- Fast Installation
- No UWP Apps , No Bloats
- Open-Shell Instead of Native Windows 10 Start Menu
- Microsoft account Sign in working
- printing and sharing files fully functional
- Bitlocker Functional
- Microsoft Games added (Spider solitaire , Minesweeper , etc..)
- Footprint after installation : 8.46GB (Windows 10 Pro Lite)
Please Note
- Burn on USB flash drive or DVD
- Don't Resume updates because updates will Fail in Installation
- Fresh install only supported using USB flash drive or DVD
What's Removed/Not Working
- Windows Updates
- Face, Fingerprint Recognition
- Voice Recognition
- Windows System Assessment Tool
- Eye Control
- Recovery Driver Creator
- System Reset Platform
- Windows Recovery Environment (WinRE.wim)
- Storage Spaces
- Store and Xbox Removed
- And all Other UWP Apps
Note. AnkhTech uses boot from Windows 7 for their WinPE. If you want to install it on Virtual PC, just choose Windows 7 in the very beginning.

https://support.microsoft.com/en-us/topic/november-11-2025-kb5068791-os-build-17763-8027-485c3175-0dc0-45c6-8328-553863ea2cbc

Homepage:

https://ankhtech.weebly.com/

Rapidgator

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[mitsumi1]

Windows 10 Pro Lite / SuperLite 22H2 Build 19045.6456 x64 Multilanguage Preactivat...

Free Download Windows 10 Pro Lite / SuperLite 22H2 Build 19045.6456 x64 Multilanguage Preactivated AnkhTech
WPE+ Bootable | Language: English, Arabic, Spanish, Portuguese, French | File Size: 2.98 GB
Introducing 1 of best Windows 10 Pro Modified ISO with a Multi functional/Multi Purpose Boot 5 Languages in installation and the ability to install more languages. With support for all Computers/Laptops modern & old. Looks original and native by Microsoft, but way much faster performance, speed and stability.



Multi Functional Boot (WinPE)
- Multi Functional Powerful Boot with Professionals Programs to help you, Taskbar Shows up when you Move your Mouse Cursor Down in the Screen
- Take and Restore Backups, Test Your PC/Laptop Hardware, Do disk management tasks, Manage your files before installing the windows
Programs in Boot
- Monitor Test
- Unlocker
- 7zip
- AOMEI Partition Assistant
- Battery Mon
- BitlockerKey
- Boot Sect Gui
- BOOTICE
- Core Temp
- CPU-Z
- Crystal Disk Info
- Crystal Disk Mark
- Disk2VHD
- Everything
- Fast Copy
- File Explorer
- gimagex
- HD Speed
- HW Monitor
- HWinfo
- ImDisk
- Minitool Partitions wizard Ultimate
- NTFS Driver Protection
- NTPWedit
- PEPassPass
- Q-Dir
- Quick Memory Test
- Ram Test
- Search
- SearchMyFiles
- Snapshot
- Symantec Ghost
- Terabyte Image
- Windows Login Unlocker
- WinNT Setup
With 4 Editions you have the choice
1 - Windows 10 Pro Lite + Windows Defender
Windows Features can be Modified , Install more Languages , Protection against Viruses
2 - Windows 10 Pro Lite
Windows Features can be Modified , Install more Languages
3 - Windows 10 Pro Superlite + Windows Defender
Windows Features Can Not be Modified , Can Not Install more Languages , Protection against Viruses , Very Fast installation and small sized Footprint after installation and little higher speed system
4 - Windows 10 Pro Superlite
Windows Features Can Not be Modified , Can Not Install more Languages , Very Fast installation and small sized Footprint after installation and little higher speed system
Minimal amount of UWP Apps
- Microsoft Store
- Xbox , Xbox game bar
- Snipping tool
- Calculator
- Camera
- Sound Recorder
- Alarms & Clock
Tweaks
- Windows Photo Viewer Enabled, Reserved Storage disabled
- Fast Startup enabled, Reduce shutdown time
- Hibernation Disabled
- Updates Paused until 2050
- Context Menu: Take Ownership Added, Windows Mode (Dark/Light) Added
Enabled
- Direct Play , Legacy Components
- Net framework 3.5 installed
- Microsoft store applications and xbox games working
- Microsoft account Sign in working
- printing and sharing files fully functional
- Bitlocker Functional
- Microsoft Games added (Spider solitaire , Minesweeper , etc..)
Please Note
- Burn on USB flash drive or DVD
- Don't Resume updates because updates will Fail in Installation
- Fresh install only supported using USB flash drive or DVD
What's Removed/Not Working
- Windows Updates
- Face Recognition
- Voice Recognition
- Narrator
- Windows System Assessment Tool
- Eye Control
- Recovery Driver Creator
- System Reset Platform
- Windows Recovery Environment (WinRE.wim)
- Storage Spaces
Note. AnkhTech uses boot from Windows 7 for their WinPE. If you want to install it on Virtual PC, just choose Windows 7 in the very beginning.

https://support.microsoft.com/en-us/topic/october-14-2025-kb5066791-os-builds-19044-6456-and-19045-6456-657e5143-6c5d-4401-8efa-1641ca93c051

Homepage:

https://ankhtech.weebly.com/

Rapidgator

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[mitsumi1]

Windows 7 Professional SP1 Multilingual Preactivated November 2025

Windows 7 Professional SP1 Multilingual Preactivated November 2025

Windows (x64) | Languages:Arabic,English,German,Greek,French,Spanish,Italian,Portuguese-Portuguese,Portuguese-Brazil,Turkish,Dutch,Czech | Wim Install | File Size: 5.01 GB


Windows 7 Professional is the most versatile and powerful edition of Windows 7. It combines remarkable ease-of-use with the entertainment features of Home Premium and the business capabilities of Professional, including the ability to run many Windows XP productivity programs in Windows XP Mode.For added security, you can encrypt your data with BitLocker and BitLocker To Go. And for extra flexibility, you can work in any of 35 languages. Get it all with Windows 7 Professional.

Features
-64-bit versions Combines remarkable ease-of-use with the entertainment features of Home Premium and the business capabilities of Professional--get it all with with Windows 7 Ultimate
-Make the things you do every day easier with improved desktop navigation; start programs faster and more easily, and quickly find the documents you use most often
-Run many Windows XP productivity programs in Windows XP Mode; watch, pause, rewind, and record TV on your PC
-Easily create a home network and connect your PCs to a printer with HomeGroup; connect to company networks easily and more securely with Domain Join
-Recover your data easily with automatic backup to your home and business network; help protect data on your PC and portable storage devices against loss or theft with BitLocke


HOMEPAGE

https://www.microsoft.com/en-pk/

DOWNLOAD

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[mitsumi1]

Windows 7 Ultimate SP1 Multilingual Preactivated November 2025

Windows 7 Ultimate SP1 Multilingual Preactivated November 2025

Windows (x64) | Languages:Arabic,English,German,Greek,French,Spanish,Italian,Portuguese-Portuguese,Portuguese-Brazil,Turkish,Dutch,Czech | Wim Install | File Size: 5.02 GB


Windows 7 Ultimate is the most versatile and powerful edition of Windows 7. It combines remarkable ease-of-use with the entertainment features of Home Premium and the business capabilities of Professional, including the ability to run many Windows XP productivity programs in Windows XP Mode.For added security, you can encrypt your data with BitLocker and BitLocker To Go. And for extra flexibility, you can work in any of 35 languages. Get it all with Windows 7 Ultimate.

Features
-64-bit versions Combines remarkable ease-of-use with the entertainment features of Home Premium and the business capabilities of Professional--get it all with with Windows 7 Ultimate
-Make the things you do every day easier with improved desktop navigation; start programs faster and more easily, and quickly find the documents you use most often
-Run many Windows XP productivity programs in Windows XP Mode; watch, pause, rewind, and record TV on your PC
-Easily create a home network and connect your PCs to a printer with HomeGroup; connect to company networks easily and more securely with Domain Join
-Recover your data easily with automatic backup to your home and business network; help protect data on your PC and portable storage devices against loss or theft with BitLocker.

Net 3.5 Enabled

Whats New
Screenshots
Windows 7 Ultimate SP1 Multilingual Preactivated April 2024
Windows 7 Ultimate SP1 Multilingual Preactivated November 2025
Windows 7 Ultimate SP1 Multilingual Preactivated November 2025
System Requirements
Processor: 1 gigahertz (GHz) or faster.
RAM: 1 gigabyte (GB).
Free space on hard disk: 16 gigabytes (GB).
Graphics card: DirectX 9 graphics device or a newer version.
Additional requirements to use certain features.
To use touch you need a tablet or monitor that supports multitouch.
To access the Windows store to download and run apps, you need an active Internet connection and a screen resolution of at least 1024 x 768 pixels


HOMEPAGE

https://www.microsoft.com/en-pk/

DOWNLOAD

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[mitsumi1]

WindowTop 5.29.1 Beta Multilingual (x64)

Free Download WindowTop 5.29.1 (x64) Beta Multilingual Fast Links | 31.7 Mb
WindowTop enable you to pin any window on top, enable window transparency, even click through transparent window, set window dark/read mode, shrink the window to small size and more.


Always on Top
Easily set window on top and even highlight top-most window with a red frame! You can configure this behavior in settings (frame color, etc).
Anchors
The reason why you may put a window on top is to get back to it faster.
If this is your case, then Anchors is for you! Instead of using Always-on-Top, just use Anchors! They will help you to access the window with a single click! Faster than ALT+TAB, great for touch screens!
And don't worry, the anchors will not disturb you because they automatically move away from any text/image
PiP for any window!
Want to watch some video while working?
No problem! Shrink it! It will enable PiP mode.
In addition, you can even interact with the window while it is in PiP/Shrink mode (See the example!)
PiP Auto-Move!
PiP also come with auto-move option!
It will stay away from text/images for you!
Opacity
Working on something like building a website and want to see your work behind? No problem! Use opacity
Opacity + Click Through
Opacity also includes a feature that allows you to click through a transparent window. This can be useful for designers and graphic artists.
Dark Mode
Working at night? Tired of all the light coming out of the screen and unfortunately, the software does not support dark mode? No problem now!
Note: Unstable in Windows 10 (Stable in Windows 11)
Operating System:Windows 10, 11
Home Page -

https://windowtop.info/

Rapidgator

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[mitsumi1]

WindowTop Pro 5.29.1 Beta Multilingual

WindowTop Pro 5.29.1 Beta Multilingual

Windows x64 | File size: 67.08 MB


WindowTop enable you to pin any window on top, enable window transparency, even click through transparent window, set window dark/read mode, shrink the window to small size and more.

Always on Top
Easily set window on top and even highlight top-most window with a red frame! You can configure this behavior in settings (frame color, etc).

Anchors
The reason why you may put a window on top is to get back to it faster.
If this is your case, then Anchors is for you! Instead of using Always-on-Top, just use Anchors! They will help you to access the window with a single click! Faster than ALT+TAB, great for touch screens!
And don't worry, the anchors will not disturb you because they automatically move away from any text/image

PiP for any window!
Want to watch some video while working?
No problem! Shrink it! It will enable PiP mode.
In addition, you can even interact with the window while it is in PiP/Shrink mode (See the example!)

PiP Auto-Move!
PiP also come with auto-move option!
It will stay away from text/images for you!

Opacity
Working on something like building a website and want to see your work behind? No problem! Use opacity

Opacity + Click Through
Opacity also includes a feature that allows you to click through a transparent window. This can be useful for designers and graphic artists.

Dark Mode
Working at night? Tired of all the light coming out of the screen and unfortunately, the software does not support dark mode? No problem now!
Note: Unstable in Windows 10 (Stable in Windows 11)

Glass Mode
Smart transparency mode enables you to take opacity to the next level! Unlike regular transparency, you can set different opacity levels for the background around the text/controls and the images.
And you can even set the blur level.
Note that this may work slowly on 4K and will work better for NVIDIA GPUs (make use of CUDA feature)


HOMEPAGE

https://windowtop.info/

DOWNLOAD

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[mitsumi1]

XL-Connector 3.6.28

Free Download XL-Connector 3.6.28 | 309.3 Mb
XL-Connector is a popular plugin that safely integrates Excel and Salesforce to seamlessly export, import, refresh and transform data with a lightning fast-api connection. It offers Salesforce admins a comprehensive toolbox that easily performs data and metadata management operations in a familiar Excel environment.


Your ideal tool for Salesforce data management in Excel
Export from Salesforce to Excel
Pull data from an existing Salesforce report or build your own SOQL query directly into Excel.
Import data into Salesforce
Manage and transform your data in Excel, and push it back with one click.
- Use all the amazing Excel tools on your Salesforce dаta: pivot tables, charts, and formulas.
- Perform any data operation with no row limits!
- Ideal Salesforce data cleansing tool
- Access great metadata management tools
Get the most valuable Salesforce plugin for excel
- Saves hours and days of data-loading.
- Image not found
- Private and secure.
- Image not found
- Boosts team productivity.
- Amazing features for data manipulation.
- Image not found
- Improves the quality of your data by keeping it up to date.
Perform and automate any data operation in bulk
Mass create, update and upsert opportunities, accounts, leads, codes and other SFDC objects with XL-Connector. Become a master of bulk updates and upserts in Salesforce with just a click of a button!
Manage your Salesforce duplicate records
Efficiently merge Salesforce Accounts, Contacts, and Leads in bulk (available in the Enterprise Admin edition).
Delete your Salesforce records in bulk
Mass delete records in Salesforce and keep your data fresh and updated.
Perform your Salesforce Data Migration with the help of XL-Connector
Safely migrate large amounts of data.
XL-Connector: Your Ideal tool for Salesforce metadata management.
XL-Connector is the only Excel to Salesforce connector that provides a complete assortment of metadata management tools that will hugely boost the productivity of Salesforce admins.
These tools enable management of such things as fields, validation rules, processes, picklists, security settings, custom metadata and much more. Tasks that normally take days, like updating the descriptions and help texts of data fields, will take minutes with XL-Connector.
Other XL-Connector great features you will appreciate
Super intuitive user interface
A climax between simplicity and comprehensiveness, The user interface is very friendly and presents a minimal learning curve.
Security by design
XL-Connector is a locally installed app that doesn't send your data anywhere outside of your secure environment. There's no cloud component to it, so the data travels directly between your PC and Salesforce instance over a secure encrypted channel.
Home Page -

https://www.xappex.com/

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[mitsumi1]

Comsol Multiphysics 6.4 Build 293 Win x64 Multilanguage

Free Download Comsol Multiphysics 6.4 Build 293 Win x64 Multilanguage | 12.3 Gb
Languages Supported: Simplified 中文, Traditional 中文, English, Français,
Deutsch, Italiano, 日本語, 한국어, Español.
COMSOL, a global leader in modeling and simulation software, has announced the release of COMSOL Multiphysics version 6.4, , which adds new features, performance updates and expanded tools for multiphysics modeling and simulation app development. The latest version includes improved solver performance through the NVIDIA CUDA direct sparse solver, NVIDIA cuDSS, support for NVIDIA AI infrastructure, a new Granular Flow Module and a new framework for time-explicit dynamic analysis.
Owner:COMSOL AB
Product Name:Comsol Multiphysics
Version:6.4 (293)
Supported Architectures:x64
Website Home Page :www.comsol.com
Languages Supported:multilanguage
System Requirements:Windows *
Size:12.3 Gb


In addition to the new features, version 6.4 includes updates to geometry, meshing and visualization workflows. The release also adds optional large language model-assisted simulation. The Chatbot window now supports connections to GPT-5, DeepSeek, Google Gemini, Anthropic Claude and other OpenAI API-compatible models, allowing users to access documentation and information from the active simulation in one place.
COMSOL releases Multiphysics 6.4 with new modules and GPU tools
Version 6.4 adds GPU-accelerated solvers, a Granular Flow Module, and updates to workflows for geometry, meshing and visualization.

In-cabin acoustic simulations, such as the one shown here of a car cabin, benefit from NVIDIA GPU acceleration in version 6.4, which offers faster and more scalable analyses.
Faster simulations with GPU-accelerated solvers
Version 6.4 introduces NVIDIA GPU acceleration for direct solvers and expands multi-GPU support for acoustics simulations. The cuDSS sparse direct solver, designed for hybrid CPU-GPU computation, supports recent NVIDIA GPU architectures and can provide speed improvements depending on hardware and model size. GPU acceleration can be useful for both single-physics and multiphysics simulations, especially when solver stability is important. The NVIDIA CUDA-X cuBLAS library also accelerates transient pressure acoustics simulations, which can now run on multiple GPUs in a single system or on a GPU cluster. These updates reduce computation time for larger models.

The new Granular Flow Module can be used to analyze mixing performance and quantify homogeneity in industrial blending equipment.
Granular flow modeling for particle-based processes
The Granular Flow Module, a new add-on based on the discrete element method (DEM), allows users to model particle motion in applications such as hopper discharge, silo storage, chute transport, powder spreading and mixing. It can be applied in fields including pharmaceuticals, chemical processing, agriculture, mining and additive manufacturing. The module accounts for particle-level behavior such as collisions, adhesion and rotational resistance, and provides controls for particle properties, release conditions and wall interactions. These capabilities help evaluate flow uniformity, packing density, mixing behavior and wall stresses, and can identify issues such as blockages or uneven flow.

Explicit structural dynamics capabilities enable a new class of simulations in COMSOL Multiphysics version 6.4, including drop tests of handheld consumer electronics.
Time-explicit dynamic analysis framework
Version 6.4 adds a framework for time-explicit dynamic analysis to simulate fast, transient and highly nonlinear events, including impact, crushing and elastic wave propagation. The explicit approach supports nonlinear structural materials such as hyperelastic, plastic, viscoplastic and creep models, and can be used with dynamic fracture simulations. To simplify setup for mechanical assemblies, the software can automatically detect and define contact conditions between interacting components.
Updates across the product suite
Other changes in COMSOL Multiphysics version 6.4 include:
- Improved quad-dominant and swept meshing
- Support for spatially varying transparency
- Array-based Description layouts
- More efficient development of large simulation apps
- New optimization options for time-dependent and parametric studies
- Export of network parameters for DNN surrogate models
- Surrogate model data generation on clusters
- Import of CFD data in CGNS format
- Frequency- and time-dependent uncertainty quantification

COMSOL Multiphysicsis a general-purpose simulation software used in all fields of engineering, manufacturing, and scientific research. The software brings fully coupled multiphysics and single-physics modeling capabilities, model management, and user-friendly tools for building simulation applications. Spread the value of simulation to your design teams, manufacturing departments, test labs, customers, and other collaborators by distributing your apps using COMSOL Compiler and COMSOL Server. Add-on modules provide specialized functionality for electromagnetics, structural mechanics, acoustics, fluid flow, heat transfer, and chemical engineering. Interfacing products are available for CAD and other third-party software. All add-on products from the product suite connect seamlessly with COMSOL Multiphysics for a modeling workflow that remains the same regardless of what you are modeling.
COMSOL Multiphysics Tutorial for Beginners
This tutorial video series introduces you to the modeling workflow. Follow the series to see the set-up and solution of a multiphysics model of Joule heating and thermal expansion in a thermo-electro-mechanical MEMS actuator.
Svante Littmarck and Farhad Saeidi foundedCOMSOL ABin 1986 in Stockholm, Sweden. Since then, the company has grown into a group of subsidiaries spread around the world. Today, Svante Littmarck is the CEO of the COMSOL Group and the president and CEO of COMSOL, Inc. Farhad Saeidi is the president of COMSOL AB. The group flagship product, COMSOL Multiphysics, is used in all fields of engineering, manufacturing, and scientific research for modeling multiphysics systems. Our customers use the software to understand, predict, innovate, and optimize product designs and processes.

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[mitsumi1]

AllMapSoft Offline Map Maker 8.363

Free Download AllMapSoft Offline Map Maker 8.363 | 11 Mb
Offline Map Maker is a tool that help you to get offline tile images from many online maps providers, including 500+ maps types.


It supports multi-zoom level images download, supports kml and gpx as input parameters, can output html files for leaflet, openlayers and googleapi, can output bmp, jpg, tif, png, ecw, sgi, img, kmz as a big map, can output mbtiles for mobile apps to use.
Operating System:Windows 7, 8/8.1, 10
Home Page -

http://www.allmapsoft.com/

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