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Pathologies of Calcium Channels by Norbert Weiss, Alexandra Koschak
English | November 26, 2013 | ISBN: 364240281X | 749 pages | EPUB | 4.68 Mb
Calcium ions represent Mother Nature's 'ion-of-choice' for regulating fundamental physiological functions, as they initiate a new life at the time of fertilization and guide subsequent developmental and physiological functions of the human body. Calcium channels, which act as gated pathways for the movement of calcium ions across the membranes, play a central part in the initiation of calcium signals, and defects in calcium channel function have been found to result in a plethora of human diseases, referred to as the calcium channelopathies.

Pathologies of Calcium Channels brings together leading international experts to discuss our current understanding of human diseases associated with the various calcium channels, from their molecular basis to potential future therapeutic targeting of calcium channels.

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Paupers, Parties and Plagues: The History of Everyday German Peasants Vol. 2, 1450 - 1850 by David Koehler
English | July 27, 2023 | ISBN: N/A | ASIN: B0CD32JK8M | 283 pages | EPUB | 12 Mb
David Koehler continues his history of German peasants with this brilliant second volume, the companion to Bakers, Brewers and Bricklayers (2022), which was nominated for a Midwest Book Award.

Paupers, Parties and Plagues, written in a vivid non-academic style, shows how this hardy people survived waves of war, plague and famine yet managed to invent the first printing press, oil lamps, iron stoves, the pivoting front cart axle, cuckoo clocks and stagecoaches between 1450 and the mid-19th century. Koehler explains why the Industrial Revolution arrived late in German-speaking lands, and shows how the revolution of 1848, known as the "turning point when Germany did not turn", left Germans at a poverty equal to today's Sub-Saharan Africa.
The religious upheaval of the Thirty Years' War played out mostly on German soil, leaving the German-speaking world destitute and divided, which eventually leads to a mass exodus, beginning in 1820, when millions escaped poverty and despotism for freedom and food in the Americas.

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Edward Y. Lee MD MPH, "Pediatric Thoracic Imaging"
English | ISBN: 1496356233 | 2018 | 312 pages | PDF | 39 MB
Pediatric Thoracic Imaging is the first comprehensive text to focus on all aspects of pediatric congenital and acquired thoracic disorders. This text is an essential reference for pediatric radiologists, those in training and of special interest to general radiologists as well as clinicians in different pediatric medical specialties. Skillfully written by Dr. Edward Y. Lee, current President of the ISPTI (International Society of Pediatric Thoracic Imaging) of Boston Children's Hospital and Harvard Medical School with the added international perspective of five associate editors, it is an authoritative encyclopedia of diseases/disorders with more than 2,000 high-quality images of radiography, ultrasound, CT, MRI, nuclear medicine and more.

Sections organized by lung, large airways, mediastinum, heart, chest wall, and diaphragm presenting the imaging modalities and options for pediatric congenital and acquired thoracic disorders
Read more

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Penman of the Founding: A Biography of John Dickinson
by Jane E. Calvert
English | 2024 | ISBN: 0197541690 | 620 Pages | PDF | 29 MB

Why is it that so many Americans have not heard of John Dickinson?
John Dickinson of Pennsylvania and Delaware was an early leader of the resistance to British rule in the American colonies. In fact, to many, he was the most prominent figure in the struggle for independence, though his Quaker-influenced opposition to violence kept him from signing one of its most famous documents in July 1776. Still, Dickinson, one of the wealthiest men in the colonies, did more to promote the cause behind it than almost anyone else, not only as the lead draftsman in all the national Congresses, but in his popular writing. His hugely influential Letters from a Farmer in Pennsylvania educated colonists about their rights and instructed them in how to defend those rights in non-violent ways. In essence he taught the colonists to think of themselves as Americans, united in a common cause. Despite his refusal to sign the Declaration of Independence, he continued to serve the nation in a number of capacities-in Congress, as governor of Delaware and Pennsylvania, as president of the Annapolis Convention, as delegate to the Federal Convention, and as president of the Delaware constitutional convention. Because of his close association with Quakerism, he also took stances unlike any other major figure of his day, making him among the first to advocate civil disobedience as a form of protest, freeing his slaves and embracing abolitionism, advocating rights for women, Indians, prisoners, and the poor. He nonetheless volunteered for active service in the Delaware militia during the War of Independence.
Despite the key part he played in the country's founding, few Americans today have heard of John Dickinson. Early chroniclers and historians, seeking to create a patriotic narrative and taking their cues from his political enemies, cast him as a coward and Loyalist for not signing the Declaration. Many later historians have simply accepted and echoed this distorted and dismissive view. Jane Calvert's fascinating, authoritative, and accessible biography, the first complete account of Dickinson's life and work, restores him to a place of prominence in the nation's formative years.

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Performativität in der Klassischen Deutschen Philosophie
Deutsch | 2024 | ISBN: 3662696533 | 188 Pages | PDF (True) | 1.2 MB
Performativität spielt avant la lettre in der Klassischen Deutschen Philosophie eine bedeutende Rolle. Sie ist u.a. ein zentraler Bestandteil originärer Interpretationen des Absoluten, des Subjekts oder auch des Wissens. Seit den 2010er Jahren mehren sich daher Untersuchungen, die dem Performativen bei Kant, Fichte, Schelling, Hegel und in der Frühromantik nachspüren. Dieser Sammelband greift diese Entwicklung auf. Anhand interdisziplinärer Beiträge wird Performativität innerhalb der Klassischen Deutschen Philosophie erläutert und diskutiert. Dabei wird der hermeneutische und systematische Ertrag performativer Interpretationen dargestellt.

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Piezoelectric Sensors (Springer Series on Chemical Sensors and Biosensors) by Peter Lieberzeit
English | April 14, 2024 | ISBN: 303153784X | 347 pages | MOBI | 21 Mb
This book provides a comprehensive overview of piezoelectric sensor devices and instrumentation and their use for chemical and biochemical analysis. Sensors relying on established transducers, such as the quartz crystal microbalance (QCM) and the surface acoustic wave resonator (SAW) are covered, and novel devices like surface transverse wave (STW) resonators, film bulk acoustic resonators (FBAR) as well as non-piezoelectric devices with mass-sensitive properties are presented. As their name implies, such devices respond directly to mass changes on their surfaces and thus address the most fundamental quality of any analytes. First, the book presents the fundamentals of new measuring strategies with these devices. Then, it introduces a variety of chemo- and biosensing application scenarios of these devices. In addition, the book covers both the state-of-the-art of academic research and prospects concerning the commercialization of these sensors. Given its scope, the book is of interest to academics, specialists in industry, and advanced students in the areas of analytical chemistry, rapid analysis, and sensor technology, giving them the unique possibility to familiarize themselves with this chemical sensing strategy. Readers will benefit from the coverage of both cutting-edge research results and applications that help bridge the gap between academia and industry.

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Simon Coleman, "Pilgrimage and Political Economy: Translating the Sacred"
English | ISBN: 1785339427 | 2018 | 206 pages | PDF | 3 MB
Pilgrimage has always had a tendency to follow―and sometimes create―trade routes. This volume explores how wider factors behind transnational and global mobility have impacted on pilgrimage activity across the world, and examines the ways in which pilgrimage relates to migration, diaspora, and political cooperation or conflict across nation-states. Furthermore, it brings together case studies that explore forms of mobility where pilgrimage is juxtaposed, complements, or is in intimate association with other forms of movement.

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Plato: A Civic Life
by Carol Atack
English | 2025 | ISBN: 1789149460 | 240 Pages | True ePUB | 5.5 MB

A new reading of Plato's philosophy that reveals it as deeply shaped by his experiences in Athens.
Plato is a key figure from the beginnings of Western philosophy, yet the impact of his lived experience on his thought has rarely been explored. Born during a war that would lead to Athens' decline, Plato lived in turbulent times. Carol Atack explores how Plato's life in Athens influenced his thought, how he developed the Socratic dialogue into a powerful philosophical tool, and how he used the institutions of Athenian society to create a compelling imaginative world. Accessibly written, this book shows how Plato made Athens the place where diverse ideas were integrated into a new way of approaching the big questions about our lives, then and now.

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John Bartle, Dylan Griffiths, "Political Communications Transformed: From Morrison to Mandelson"
English | 2001 | pages: 225 | ISBN: 0333776763, 1349417254 | PDF | 1,3 mb
Dramatic changes in society, technology and culture have transformed the relationship between political parties, the media, and the individual voter over the last fifty years. The leading researchers gathered in this volume offer a comprehensive analysis of the evolution of British political communication since 1945. They explore the competition for coverage between political parties and media organizations, the ongoing rivalry between politicians and the press, and the implications for the quality of British democracy.

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Polytropos Ajax: Roots, Evolution, and Reception of a Multifaceted Hero
by Silvia Speriani and Stephen Harrison
English | 2024 | ISBN: 311145035X | 231 Pages | True ePUB | 25 MB

Meanings are realized at the point of reception and this volume intends to offer an in-depth discussion of some of the meanings associated with and raised by the figure of Telamonian Ajax at various, specifically contextualized, and yet somehow connectable 'points of reception'.
Part 1 looks at how, and from where, and with what effects, the epic and tragic figure of Ajax is constructed and re-defined in archaic and classical Greece. Part 2 moves on to Roman Ajax(es), evaluating how he is used in and by Latin literature as a tool for window-references and innovation, and for reflecting on national identity and cultural categories. Part 3 discusses various ways in which the myth of Ajax, especially in its Sophoclean version, has been translated into theatrical, psychological, and philosophical discussions.
This is not an attempt to look for Ajax's true nature (an ill-posed question in itself). Nor is it a claim to evaluate Ajax's features as if they could be placed on a straight evolutionary line (they never can be). On the contrary, the volume provides a multiform and interconnected ensemble of relevant patterns, always particularly situated, and constantly changing.

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Cas Mudde, "Populist Radical Right Parties in Europe"
English | 2007 | pages: 405 | ISBN: 0521850819 | PDF | 1,4 mb
As Europe enters a significant phase of re-integration of East and West, it faces an increasing problem with the rise of far-right political parties. Cas Mudde offers the first comprehensive and truly pan-European study of populist radical right parties in Europe. He focuses on the parties themselves, discussing them both as dependent and independent variables. Based upon a wealth of primary and secondary literature, this book offers critical and original insights into three major aspects of European populist radical right parties: concepts and classifications; themes and issues; and explanations for electoral failures and successes. It concludes with a discussion of the impact of radical right parties on European democracies, and vice versa, and offers suggestions for future research.

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Porsche 911 60 Years by Randy Leffingwell, Harm Lagaaij
English | April 16, 2024 | ISBN: 0760382654 | 304 pages | MOBI | 41 Mb
Celebrate six decades of rear-engine excellence with this beautifully illustrated exploration of 60 milestone Porsche 911s.

Porsche's 911 is the quintessential sports car-focused, purposeful, race-proven, and exciting. Since its prototype debut in 1963, the 911 has defied expectations while never losing its form or its giant-slaying heart.
In Porsche 911 60 Years, best-selling Porsche author Randy Leffingwell delves into the stories of sixty 911s-one from each year from 1964 to 2024. The 911's entire history-engineering, design, development,racing, and culture-is revealed one fantastic car at a time. This unique approach to the 911's legacy includes such icons as:
1964 901 Cabriolet prototypeBruce Jennings 1967 911 S1971 911 S SafariLouise Piech 1975 930 TurboLe Mans-winning 1980 935 K31987 Ruf CTR Yellowbird1991 964 Carrera RS1997 Ruf Turbo R1998 996 GT1 Le Mans winner2006 50th Anniversary Porsche Club of America 911 coupe2010 911 Sport Classic2018 Turbo S Exclusive2023 DakarAnd many more
Porsche 911 60 Years is alsothe story of the people behind the cars: Ferdinand "Butzi" Porsche, who co-designed the 911's timeless shape and his successors, Anatole Lapine, Harm Laggaaij, and Michael Mauer;Peter W. Schutz, the Porsche CEO who saved the 911 from the cutting-room floor and the Porsche leaders who carried on, most notably Wendelin Wiedeking; engineering geniuses such as Dr. Helmuth Bott, Hans Mezger, and Valentin Schaeffer; and stylists and modelers Gerhard Schroeder, Heinrich Klie, Peter Reisinger, Anthony Hatter, and Grant Larson.
Each profiled car is accompanied by historic photography from Porsche's own archive, and beautiful, contemporary photography features throughout. Porsche 911 60 Yearsis an essential volume for any Porsche owner or fan's collection.

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Poverty and Protest as Public Discourse during the Cotton Crisis
English | 2024 | ISBN: 3031733053 | 297 Pages | PDF EPUB (True) | 5 MB
This book constitutes the first book-length study of journalistic responses to poverty and protest during the Lancashire cotton crisis. The cotton crisis of 1861-1865 is a popular subject in history, culture and education. Workers' voices are comprehensively studied in terms of newspapers publishing fiction and poetry, and the broader political response to the crisis, the American Civil War and British workers' support of Lincoln's Emancipation Proclamation. They are, though, overlooked in terms of journalistic representation of workers. Ironically, discussions of the cotton crisis, including where efforts are made to assess the workers' experience, have consistently relied upon journalism as primary sources and the first witness of history without assessing the news copy's political unconscious. This lack of attention is especially apparent when considering workers challenging poverty through dedicated protest. Amid the celebrated workers' opposition to slavery, and their 'sublime heroism' as noted by American President Abraham Lincoln, there were less studied local struggles for financial help, for education, and for the vote.

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Power in Numbers: State Formation and Christianization on the Eastern Edge of Europe
by Ivo Stefan and Maria Vargha
English | 2024 | ISBN: 2503608612 | 310 Pages | PDF | 8.75 MB

Around the turn of the first millennium, the political and religious landscape of Central Europe began to change dramatically. As the decentralized pagan societies along its borders became Christian, the polity that later became the Holy Roman Empire began to expand significantly according to the principles of the Imperium Christianum - an idea that first originated with Charlemagne, but that was consciously revived by Emperor Otto I and his predecessors as a way of extending power and authority into the Empire's newly converted eastern fringes. This acculturation was effective, and societies began to actively adopt the new ideology and social order on their own initiative. Drawing on material first presented at conferences held in the Department of Archaeology at Charles University, Prague, this volume draws together researchers working on different yet connected events along the Empire's eastern frontier, and the often-overlooked part of society who nevertheless participated in these events, in particular commoners and the rural population. The papers gathered here cover affairs of the early state and church, networks of archaeological and historical heritage, and archaeological, historical, and digital investigations, to offer a blend of both synthetic archaeological and historical overviews and more focused geographical and thematic case studies that explore the role of Christianization in the centralization processes that occurred at the edge of the Ottonian-Salian world. The result is a forward-looking volume that seeks to explore new approaches to historical narratives, in particular by emphasizing the importance of archaeological material in examining early state formation and religious change. Moreover, it is the first synthetic study to directly compare the north-east and south-east peripheries of the later Holy Roman Empire, making it possible to shed new light on these lands at the periphery of Western Christendom.

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Practical Game Design - Second Edition: A modern and comprehensive guide to video game design by Adam Kramarzewski, Ennio de Nucci
English | August 18, 2023 | ISBN: 1803245158 | 446 pages | EPUB | 16 Mb
Arm yourself with the practical skills and cutting-edge insights necessary to successfully design captivating games across a variety of genres and platforms

Key FeaturesMaster the skills, processes, and techniques essential for working in a professional settingGrasp the core principles and processes of level design, world building, and storytellingDesign, implement, and refine high-quality features and mechanics for contemporary video gamesBook Description
If you're in search of a cutting-edge actionable guide to game design, your quest ends here! Immerse yourself in the fundamentals of game design with expert guidance from veterans with decades of game design experience across a variety of genres and platforms.
The second edition of this book remains dedicated to its original goal of helping you master the fundamentals of game design in a practical manner with the addition of some of the latest trends in game design and a whole lot of fresh, real-world examples from games of the current generation. This update brings a new chapter on games as a service, explaining the evolving role of the game designer and diving deeper into the design of games that are meant to be played forever. From conceptualizing a game idea, you'll gradually move on to devising a design plan and adapting solutions from existing games, exploring the craft of producing original game mechanics, and eliminating anticipated design risks through testing. You'll then be introduced to level design, interactive storytelling, user experience and accessibility.
By the end of this game design book, you'll have learned how to wrap up a game ahead of its release date, work through the challenges of designing free-to-play games and games as a service, and significantly improve their quality through iteration, playtesting, and polishing.
What you will learnDefine the scope and structure of a game projectConceptualize a game idea and present it to othersDesign gameplay systems and communicate them clearly and thoroughlyBuild and validate engaging game mechanicsDesign successful games as a service and prepare them for live operationsImprove the quality of a game through playtesting and meticulous polishing
Who this book is for
Whether you are a student eager to design your very first game or a game designer looking to expand your skill set, this book will help you master the fundamentals of game design across all stages of game development. With a focus on best practices and a pragmatic approach, Practical Game Design offers insights into the art and craft of game design from two senior game designers, with insider knowledge that even veterans will find valuable. While prior experience with game development is not absolutely necessary, having basic knowledge of popular video games will prove helpful.
Table of ContentsIntroducing the Game Production ProcessPreparing a Game ConceptScoping a Game ProjectCreating Design DocumentationUnderstanding Game MechanicsDesigning Systems and FeaturesMaking PrototypesDesigning Compelling Stories for GamesThe Fundamentals of Level DesignCreating CharactersBalancing Your Content and SystemsBuilding a Great User Interface and User ExperienceMaking Your Games AccessibleMastering Games as a ServiceUnderstanding Monetization TechniquesThe Final 10%

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